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「幹細胞外泌體」
腦損傷與神經退化疾病就目前科學所知是不可逆的症狀，而多數神經退化疾病與腦損傷會引起失智，在台灣估計已經有超過27萬的失智人口，此恐為邁入高齡社會必須面對的挑戰。除了高齡，各種程度的碰撞、不正常的生活習慣、高血壓、糖尿病、長期的壓力及心理疾病等，都是造成腦損傷或退化的可能因素。雖然近年來在多項臨床研究已顯示，幹細胞有望修復神經系統損傷，但因需以手術植入幹細胞，故仍須面臨細胞植入造成的併發症和形成異位組織的隱憂。
國家衛生研究院細胞與系統醫學研究所李華容副研究員研究團隊歷經7年的研究，發現利用特殊技術刺激間質幹細胞，可分離出具有修復細胞功能的「幹細胞外泌體」(Stem Cell-derived Exosomes)，並從中鑑定出促使腦神經再生及腦部功能恢復之活性物質。若對大腦受損的小鼠注射幹細胞外泌體，觀察到受損的神經細胞可以長出突觸，神經細胞的數量可以恢復到原本的6成。此研究顯示幹細胞外泌體較間質幹細胞更具有促進組織再生的能力，又能避免細胞植入手術的風險及副作用，對再生醫療帶來新的突破。此系列研究已分別於2019、2020年發表於國際再生醫學權威期刊《STEM CELLS Translational Medicine》，並獲得國外媒體專欄報導。
「幹細胞外泌體」擁三優勢 醫美應用可期
美麗醫療集團執行長溫醫師談到接觸外泌體的契機，是因為集團要跨足到預防醫學領域，進而關注再生醫學、外泌體相關國際研究，發現外泌體可促進皮膚修復，便投入醫美療程臨床研究。
溫醫師認為，外泌體擁有三大優勢，包括：
顆粒小易吸收、結構完整且生物相容性高。
保存便利、高安全性。
精準傳遞修復指令：當皮膚細胞出現異常時，會釋出外泌體向其他細胞傳達救援訊息，協助異常的地方進行再生修復。
門診中，外泌體在醫美療程有分直接使用跟複合式，直接使用包含保養品塗抹、面膜跟導入；複合式療程則搭配水光槍或滾針、雷射術後、電音等，適用於膚質改善（如毛孔、細紋、暗沉、斑、色素沉澱）、凹洞痘疤、發炎青春痘、肝斑、泛紅、落髮等。
溫醫師提到，針對臨床上比較棘手的肝斑、嚴重青春痘、異位性皮膚炎、疤痕、酒糟性皮膚炎的案例，運用外泌體搭配皮秒、水光療程來進行，發現外泌體會加速皮膚修復，且在膚質上有明顯改善。
STEM CELL EXOSOME
Brain damage and neurodegenerative diseases are irreversible symptoms as far as current scientific knowledge is concerned, and most neurodegenerative diseases and brain damage can cause dementia. It is estimated that there are more than 270,000 people with dementia in Taiwan. This may be a necessity for an aging society. challenges faced. In addition to advanced age, various degrees of collision, abnormal living habits, high blood pressure, diabetes, long-term stress, and mental illness are all possible factors that cause brain damage or degeneration. Although many clinical studies in recent years have shown that stem cells have the potential to repair damage to the nervous system, since stem cells need to be surgically implanted, there are still concerns about complications caused by cell implantation and the formation of ectopic tissue.
After seven years of research, the research team of Associate Researcher Li Huarong of the National Institute of Cellular and Systems Medicine of the National Institutes of Health discovered that using special technology to stimulate mesenchymal stem cells can isolate "stem cell-derived exosomes" with cell repair functions. Exosomes), and identify active substances that promote brain nerve regeneration and brain function recovery. If stem cell exosomes are injected into brain-damaged mice, it is observed that the damaged nerve cells can grow synapses, and the number of nerve cells can be restored to 60% of the original number. This study shows that stem cell exosomes are more capable of promoting tissue regeneration than mesenchymal stem cells, and can avoid the risks and side effects of cell implantation surgery, bringing new breakthroughs in regenerative medicine. This series of research has been published in the authoritative international regenerative medicine journal "STEM CELLS Translational Medicine" in 2019 and 2020, respectively, and has received column reports from foreign media.
"Stem cell exosomes" have three advantages and can be used in medical aesthetics.
Dr. Wen, CEO of Meili Medical Group, talked about the opportunity to get into contact with exosomes because the group wanted to enter the field of preventive medicine and then pay attention to international research on regenerative medicine and exosomes. He found that exosomes can promote skin repair, so he invested in them. Clinical research on medical aesthetic treatments.
Dr. Wen believes that exosomes have three major advantages, including:
1. The particles are small, easy to absorb, have a complete structure, and have high biocompatibility.
2. Convenient storage and high security.
3. Precisely transmit repair instructions: When skin cells are abnormal, exosomes will be released to convey rescue messages to other cells, assisting the regeneration and repair of abnormal areas.
In outpatient clinics, exosomes can be used in medical aesthetic treatments either directly or in combination. Direct use includes the application of skin care products, facial masks, and introduction; compound treatments include water guns or roller needles, laser surgery, electronic music, etc. It is suitable for improving skin texture (such as pores, fine lines, dullness, spots, and pigmentation), acne scars, inflamed acne, liver spots, redness, hair loss, etc.
Dr. Wen mentioned that for clinically difficult cases of liver spots, severe acne, atopic dermatitis, scars, and rosacea dermatitis, exosomes were used in combination with picosecond and hydrophototherapy, and it was found that exosomes experienced accelerated skin repair and significant improvement in skin texture..
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